The Raman flow bench is a key component of the Raman flow assembly system that brings Raman spectroscopy to downstream bioprocessing. This Raman flow assembly system meets the speed demands of downstream by optimizing Raman collection for low-turbidity, low volume samples. Ideally suited for development-scale flow rates, it provides real-time process monitoring, rapid optimization, and control for chromatography and other downstream unit operations.
Downstream: aggregation, protein crystallization, formula stability, product CQA, protein concentration, buffer excipients
Midstream: analyte monitoring in permeate
Výhody
The Raman flow bench houses a Raman flow cell and easily connects to an Rxn-10 probe paired with a Raman Rxn embedded analyzer
Brings Raman-based process insights and control to downstream bioprocessing unit operations
Incorporates ambient light control as well as signal amplification
Ramanova spektroskopie – pokročilá technologie pro optickou analýzu
Zvyšte bezpečnost provozu, zajistěte kvalitu výrobků a optimalizujte řízení. Ramanova spektroskopie měří složení a molekulární strukturu vašich vzorků v reálném čase – z laboratoře přímo do procesu.
KBI Biopharma is monitoring a diverse array of cell lines and cell concentrations in minimal volume for automated cell cultivation in the Life Sciences industry.
Graphic illustrating the core elements of Biopharma 4.0 including product lifecycle stages, role of PAT/QbD, and 12 key advanced technologies for scientists and process engineers in the Life Sciences, applicable to Raman spectroscopy systems (Raman Rxn2, Raman Rxn4, Rxn-10, Rxn-45, Rxn-46, bio multi optic and sleeve, flow cell and flow bench, Raman optic system for single use, and Raman calibration & verification kits).
Raman flow assembly - Precise composition measurement of
high-speed, low-volume samples in downstream bioprocessing
PU (publikace)
Anglická verze - 05/2023
New version available in English
An overview of the Raman flow assembly (flow bench and flow cell) used with the Rxn-10 probe in conjunction with a Raman Rxn2 analyzer and a Raman flow assembly calibration and verification kit for downstream bioprocessing (powered by Kaiser Raman technology).
Body: 316L stainless steel Window: Proprietary material, optimized for bioprocesses Surface finish: Ra 15 with Electropolish to ASME BPE SF4 finish Adhesive: USP Class VI and ISO 10993 compatible
With non-contact and immersion optic: 532 nm, 785 nm, 1000 nm With bIO-Optic or Raman optic system for single use: 785 nm, 1000 nm With bio multi optic and bio sleeve or Raman flow assembly: 785 nm
Body: 316L stainless steel Window: Proprietary material, optimized for bioprocesses Surface finish: Ra 15 with Electropolish to ASME BPE SF4 finish Adhesive: USP Class VI and ISO 10993 compatible
With non-contact and immersion optic: 532 nm, 785 nm, 1000 nm With bIO-Optic or Raman optic system for single use: 785 nm, 1000 nm With bio multi optic and bio sleeve or Raman flow assembly: 785 nm
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